Valois rivalry with Spain began in 1494 when Charles VIII of France invaded Italy to claim the Kingdom of Naples through the Angevin inheritance from Rene of Provence.
- Spain had a claim over Naples through the Aragonese line.
France was kicked out of Italy in 1495.
Rivalry got stronger when Francis I became king in 1515.
Francis I sought to expand French influence in Italy and challenge Habsburg dominance.
Existing tensions with Habsburgs over Burgundy.
Francis I claimed the title of Milan through his grandmother, Valentina Visconti.
Habsburgs controlled Milan through Charles V.
Led to more wars.
Ottoman-Spain rivalry began after 1492.
- Ottomans gave refuge to Muslim and Jewish refugees from Spain.
- Supported the Moriscos.
- 1516, Ottomans conquered Egypt and Syria, gaining control over the Red Sea and threatening Spanish interests in the Mediterranean.
1526, Ottomans defeated the Kingdom of Hungary at the Battle of Mohács and killed King Louis II of Hungary and Bohemia.
- Led to a power vacuum in Hungary.
- Charles V sought to assert Habsburg control over Hungary through his brother, Ferdinand I.
Led to ongoing conflicts between the Ottomans and Habsburgs in Eastern Europe and the Mediterranean.
Charles V invaded Algeria in 1541 but was repelled.